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Literature summary for 1.13.11.40 extracted from

  • Coffa, G.; Brash, A.R.
    A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation (2004), Proc. Natl. Acad. Sci. USA, 101, 15579-15584.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.40

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cells Plexaura homomalla

Protein Variants

Protein Variants Comment Organism
A417G converts arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid, mutant retains 38% of catalytic efficiency Plexaura homomalla
A417S same oxygenase specificity and similar catalytic activity to wild-type 8S-LOX Plexaura homomalla

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
 arachidonate
-
 Plexaura homomalla

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Plexaura homomalla
-
 (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
-
 ?
arachidonate + O2 Plexaura homomalla
-
 (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Plexaura homomalla
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Plexaura homomalla (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
-
 ?
arachidonate + O2
-
 Plexaura homomalla (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
8S-LOX
-
 Plexaura homomalla

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.3
-
 arachidonate
-
 Plexaura homomalla