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Literature summary for 1.13.11.34 extracted from

  • Park, N.Y.; Im, S.; Jiang, Q.
    Different forms of vitamin E and metabolite 13-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13-carboxychromanols are competitive inhibitors of 5-lipoxygenase (2022), J. Nutr. Biochem., 100, 108884 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
delta-tocopherol-13'-carboxychromanol competitive, compound decreases leukotriene B4 from stimulated neutrophil-like cells without affecting translocation of 5-Lox from cytosol to the nucleus. Compound additionally inhibits cyclooxygenases Cox-1 and Cox-2 Homo sapiens
delta-tocotrienol competitive, compound decreases leukotriene B4 from stimulated neutrophil-like cells without affecting translocation of 5-Lox from cytosol to the nucleus. Compound additionally inhibits cyclooxygenases Cox-1 and Cox-2 Homo sapiens
delta-tocotrienol-13'-carboxychromanol competitive, compound decreases leukotriene B4 from stimulated neutrophil-like cells without affecting translocation of 5-Lox from cytosol to the nucleus. Compound additionally inhibits cyclooxygenases Cox-1 and Cox-2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09917
-
-

Synonyms

Synonyms Comment Organism
5-LOX
-
 Homo sapiens
ALOX5
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
 delta-tocotrienol-13'-carboxychromanol pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0016
-
 delta-tocopherol-13'-carboxychromanol pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0022
-
 delta-tocotrienol pH not specified in the publication, temperature not specified in the publication Homo sapiens