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Literature summary for 1.13.11.34 extracted from

  • Fischer, A.S.; Metzner, J.; Steinbrink, S.D.; Ulrich, S.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Maier, T.J.
    5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity (2010), Br. J. Pharmacol., 161, 936-949.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.34

Application

Application Comment Organism
medicine direct 5-LO inhibitors are able to suppress the viability of various human tumour cells independently of 5-LO inhibition Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AA-861 competitive 5-LO inhibitor Homo sapiens
BWA4C
-
 Homo sapiens
CJ-13,610
-
 Homo sapiens
MK-886 competitive 5-LO inhibitor Homo sapiens
Rev-5901 competitive 5-LO inhibitor Homo sapiens
zileuton
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAPAN-2 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
pancreatic cancer cell
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O
-
 ?
arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Homo sapiens
5-LO
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function 5-LO products significantly contribute to tumour cell proliferation Homo sapiens