Literature summary for 1.13.11.34 extracted from

Leifert, W.; Abeywardena, M.
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity (2008), Nutr. Res., 28, 729-737.

Search for more literature for 1.13.11.34

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.015	-	arachidonic acid	-	Glycine max
0.039	-	linoleic acid	-	Glycine max

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	ferrous form of LO-1	Glycine max

Organism

Organism	UniProt	Comment	Textmining
Glycine max	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	higher affinity of arachidonate than linoleic acid for the ferrous form of lipoxygenase-1. Hydrogen abstraction step displays high kinetic isotope effects on kcat due to tunneling contributions. Lack of solvent-dependent rate-limiting steps at lower temperatures with arachidonate as substrate	Glycine max	(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?
linoleic acid + O2	lower affinity of linoleic acid than arachidonic acid for the ferrous form of lipoxygenase-1. Hydrogen abstraction step displays high kinetic isotope effects on kcat due to tunneling contributions	Glycine max	?	-	?

Synonyms

Synonyms	Comment	Organism
lipoxygenase-1	-	Glycine max
LO-1	-	Glycine max

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
31000	-	arachidonic acid	at 25°C	Glycine max

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)