Literature summary for 1.13.11.34 extracted from

Falgueyret, J.P.; Denis, D.; MacDonald, D.; Hutchinson, J.H.; Riendeau, D.
Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization (1995), Biochemistry, 34, 13603-13611.

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Activating Compound

Activating Compound	Comment	Organism	Structure
adenosine	58% of the activation with ATP	Homo sapiens
ADP	74% of the activation with ATP	Homo sapiens
ADP-beta-S	82% of the activation with ATP	Homo sapiens
AMP	68% of the activation with ATP	Homo sapiens
AMP-4-nitrophenylphosphate	77% of the activation with ATP	Homo sapiens
ATP-alphaS	118% of the activation with ATP	Homo sapiens
ATP-gammaS	80% of the activation with ATP	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
L-670,630	IC50: 0.0004 mM	Homo sapiens
L-689,065	IC50: 0.0003 mM	Homo sapiens
L-697,198	IC50: 0.00002 mM	Homo sapiens
L-702,590	-	Homo sapiens
L-702,701	IC50: 0.0015 mM	Homo sapiens
L705,302	IC50: 0.00002 mM	Homo sapiens
N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea	IC50: 0.0001 mM	Homo sapiens
ZD 2138	i.e. CAS: 140841-32-3, IC50: 0.0003 mM	Homo sapiens
zileuton	IC50: 0.01	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	i.e. 5,8,11,14-eicosatetraenoic acid	Homo sapiens	(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00002	-	IC50: 0.00002 mM	Homo sapiens	L-697,198
0.00002	-	IC50: 0.00002 mM	Homo sapiens	L705,302
0.0001	-	IC50: 0.0001 mM	Homo sapiens	N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea
0.0003	-	IC50: 0.0003 mM	Homo sapiens	L-689,065
0.0003	-	i.e. CAS: 140841-32-3, IC50: 0.0003 mM	Homo sapiens	ZD 2138
0.0004	-	IC50: 0.0004 mM	Homo sapiens	L-670,630
0.0015	-	IC50: 0.0015 mM	Homo sapiens	L-702,701
0.01	-	IC50: 0.01 mM	Homo sapiens	zileuton

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Release 2023.1 (January 2023)