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Literature summary for 1.13.11.34 extracted from

  • Riendeau, D.; Falgueyret, J.P.; Nathaniel, D.J.; Rokach, J.; Ueda, N.; Yamamoto, S.
    Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides (1989), Biochem. Pharmacol., 38, 2313-2321.
    View publication on PubMed
Search for more literature for 1.13.11.34

Activating Compound

Activating Compound Comment Organism Structure
ATP stimulates Sus scrofa
phosphatidylcholine stimulates Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
AA861 i.e. 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone, IC50: 0.004-0.01 mM Sus scrofa
BW755C CAS: 66000-40-6; IC50: 0.004-0.015 mM Sus scrofa
diphenyldisulfide IC50: 0.002-0.005 Sus scrofa
L-651,392 i.e. 4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one, + 1 mM NADH, IV50: 0.0003-0.0005 mM Sus scrofa
L-651,896 i.e. 2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol, IC50: 0.0003-0.0004 mM Sus scrofa
L-656,224 IC50: 0.0003-0.0004 mM Sus scrofa
N-methyl-2[4-(2,4,6-trimethylphenyl)phenyl]-propenehydroxamic acid IC50: 0.0005 mM Sus scrofa
Phenidone IC50: 0.005-0.01 mM Sus scrofa
quercetin IC50: 0.0003-0.0005 mM Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Sus scrofa (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0003 0.0005 IC50: 0.0003-0.0005 mM Sus scrofa quercetin
0.0003 0.0004 i.e. 2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol, IC50: 0.0003-0.0004 mM Sus scrofa L-651,896
0.0003 0.0004 IC50: 0.0003-0.0004 mM Sus scrofa L-656,224
0.0005
-
 IC50: 0.0005 mM Sus scrofa N-methyl-2[4-(2,4,6-trimethylphenyl)phenyl]-propenehydroxamic acid
0.002 0.005 IC50: 0.002-0.005 mM Sus scrofa diphenyldisulfide
0.004 0.01 i.e. 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone, IC50: 0.004-0.01 mM Sus scrofa AA861
0.004 0.015 IC50: 0.004-0.015 mM Sus scrofa BW755C
0.005 0.01 IC50: 0.005-0.01 mM Sus scrofa Phenidone