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Literature summary for 1.13.11.33 extracted from

  • Dobrian, A.D.; Huyck, R.W.; Glenn, L.; Gottipati, V.; Haynes, B.A.; Hansson, G.I.; Marley, A.; McPheat, W.L.; Nadler, J.L.
    Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice (2018), Prostaglandins Other Lipid Mediat., 136, 23-32 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus P39654 isoform 12/15 lipoxygenase, cf. EC 1.13.11.31
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Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet
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Mus musculus
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Synonyms

Synonyms Comment Organism
12/15 lipoxygenase
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Mus musculus

Expression

Organism Comment Expression
Mus musculus a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts up

General Information

General Information Comment Organism
physiological function a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts. The increase in islet 12/15 lipoxygenase parallels a decline in islet number. A 2- to 3fold increase especially in 12(S)-hydroperoxytetraeicosanoid acid mirrors the increase in 12/15 lipoxygenase expression in islets. A significant increase of platelet 12/15 lipoxygenase gene expression is found along with 12-hydroperoxytetraeicosanoid acids and 15-hydroperoxytetraeicosanoid acids Mus musculus