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Literature summary for 1.13.11.33 extracted from

  • Chen, Y.; Peng, C.; Abraham, S.A.; Shan, Y.; Guo, Z.; Desouza, N.; Cheloni, G.; Li, D.; Holyoake, T.L.; Li, S.
    Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival (2014), J. Clin. Invest., 124, 3847-3862 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.33

Application

Application Comment Organism
medicine gene ALOX15 has potential as a therapeutic target for eradicating leukemia stem cells in chronic myeloid leukemia Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
PD146176
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Mus musculus best substrate (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P39654
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 best substrate Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
15-LO
-
 Mus musculus
Alox15
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Alox15 deletion impaired LSC function by affecting cell division and apoptosis, leading to an eventual depletion of leukemia stem cells. Chemical inhibition of enzyme 15-LO function impairs leukemia stem cell function and attenuates chronic myeloid leukemia in mice. The defective chronic myeloid leukemia phenotype in Alox15-deficient animals is rescued by depleting the gene encoding P-selectin, which is upregulated in Alox15-deficient animals. Both deletion and overexpression of P-selectin affects the survival of leukemia stem cells. Loss of Alox15 causes a functional defect in leukemia stem cells Mus musculus
physiological function arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival in a murine model of BCR-ABL–induced chronic myeloid leukemia, in the absence of Alox15, BCRABL is unable to induce CML in mice Mus musculus