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Literature summary for 1.13.11.33 extracted from
- On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma (2009), Prostaglandins Other Lipid Mediat., 89, 120-125.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| mannitol | osmotic activation of nasal tissue with mannitol activates 15-LO-1 leading to increased amounts of 15(S)-hydroxyeicosatetranoic acid in nasal lavage, and the levels of 15(S)-hydroxyeicosatetranoic acid are associated with nasal symptoms | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | 15-LO-1 is an attractive pharmacological target for treatment of inflammatory respiratory diseases like asthma, rhinitis and chronic obstructive pulmonary disease | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucocorticoid | inhibits induction in monocytes | Homo sapiens | |
| interferon-gamma | inhibits induction in monocytes | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | enzyme is translocated to the membrane upon calcium challenge | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| alveolar macrophage | medium expression | Homo sapiens | - |
| colonic cancer cell | low expression | Homo sapiens | - |
| dendritic cell | medium expression | Homo sapiens | - |
| endothelial cell | low expression | Homo sapiens | - |
| eosinophil | - |
Sus scrofa | - |
| eosinophil | high expression | Homo sapiens | - |
| epithelial cell | airway | Mus musculus | - |
| epithelial cell | airway, high expression in airway epithelial cells, medium expression in cornea epithelial cells | Homo sapiens | - |
| fibroblast | low expression | Homo sapiens | - |
| mast cell | medium expression | Homo sapiens | - |
| additional information | high expression in L-1236 cells (Hodgkin ReedSternberg cells), low expression in seminal fluid | Homo sapiens | - |
| neutrophil | low expression | Homo sapiens | - |
| prostate cancer cell | low expression | Homo sapiens | - |
| reticulocyte | - |
Oryctolagus cuniculus | - |
| reticulocyte | medium expression | Homo sapiens | - |
| synovial cell | low expression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Oryctolagus cuniculus | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? | |
| arachidonate + O2 | - |
Mus musculus | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | main product is 12(S)-hydroxyeicosatetranoic acid | ? | |
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | product ratio is 9 to 1 | ? | |
| additional information | 12/15-LO can catalyse the formation of EXC4 | Sus scrofa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 12/15-LO | - |
Mus musculus |
| 12/15-LO | - |
Sus scrofa |
| 15-lipoxygenase | - |
Oryctolagus cuniculus |
| 15-lipoxygenase-1 | - |
Homo sapiens |
| 15-LO-1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | allergen challenge up-regulates the expression of 12/15-LO in airway epithelial cells in mice. Interleukin-4 and interleukin-13 are inducers | up |
| Homo sapiens | increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients. Patients with chronic obstructive pulmonary disease also display an increased expression of 15-LO-1 in bronchial biopsies. Interleukin-4 and interleukin-13 are inducers | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | pathophysiological role of the enzyme in airway inflammation and atherosclerosis. Role in cell differentiation and importance for maturation of erythrocytes and degradation of cell organells. Role in neoplasia such as prostate cancer and colon carcinoma cells | Homo sapiens |
| physiological function | pathophysiological role of the enzyme in respiratory inflammation. Mice deficient of 12/15-LO have an attenuated allergic airway inflammation compared to wild type controls | Mus musculus |
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