Application | Comment | Organism |
---|---|---|
medicine | interruption of 12-LOX catalytic activity and the 12-hydroxyeicosatetraenoic acid signaling pathway by increasing 15-LOX metabolites may be a promising target for psoriasis therapies | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Homo sapiens |
12/15-LOX | - |
Homo sapiens |
15-lipoxygenase | - |
Homo sapiens |
15-LOX | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | level of 15-LOX expression is dose-dependently induced by UVA and UVB-irradiation. Psoralen plus ultraviolet A, UVA-photochemotherapy significantly increases 15-LOX expression | up |
General Information | Comment | Organism |
---|---|---|
physiological function | 15-LOX metabolites (15(S)-hydroxyeicosatetraenoic acid, 15-hydroxyeicosatrienoic acid or 13(S)-hydroxyoctadecadienoic acid) can inhibit insulin-like growth factor II-induced 12-LOX expression and keratinocytes proliferation | Homo sapiens |