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Literature summary for 1.13.11.33 extracted from

  • Yoo, H.; Jeon, B.; Jeon, M.S.; Lee, H.; Kim, T.Y.
    Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes (2008), FEBS Lett., 582, 3249-3253.
    View publication on PubMed

Application

Application Comment Organism
medicine interruption of 12-LOX catalytic activity and the 12-hydroxyeicosatetraenoic acid signaling pathway by increasing 15-LOX metabolites may be a promising target for psoriasis therapies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
-
Homo sapiens
12/15-LOX
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Homo sapiens
15-lipoxygenase
-
Homo sapiens
15-LOX
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens level of 15-LOX expression is dose-dependently induced by UVA and UVB-irradiation. Psoralen plus ultraviolet A, UVA-photochemotherapy significantly increases 15-LOX expression up

General Information

General Information Comment Organism
physiological function 15-LOX metabolites (15(S)-hydroxyeicosatetraenoic acid, 15-hydroxyeicosatrienoic acid or 13(S)-hydroxyoctadecadienoic acid) can inhibit insulin-like growth factor II-induced 12-LOX expression and keratinocytes proliferation Homo sapiens