Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | radiation-induced upregulation of 15-LOX-2 and 15(S)-hydroxyeicosatetranoic acid by a dose of 4 Gy in head-and-neck cancer cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | 15-LOX-2 may be a potential target in radiation-targeted therapy of head-and-neck cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
radiation-inducible 15-LOX-2 expression vector in which the full-length 15-LOX-2 cDNA is inserted downstream the recombinant Egr-1 promoter (pEgr-LOX2-GFP) and transfected in head-and-neck cancer cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | 15-LOX-2 is almost undetectable in parental head-and-neck cancer cell lines FaDu and UMSCC-1 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase 2 | - |
Homo sapiens |
15-LOX-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | radiation-induced upregulation of 15-LOX-2 results in significant induction of apoptosis in head-and-neck cancer cells and and enhances killing effect of radiotherapy in head-and-neck cancer. The enzyme inhibits tumor growth through the effect of its main metabolite 15(S)-hydroxyeicosatetranoic acid on PPARgamma signaling pathway | Homo sapiens |