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Literature summary for 1.13.11.33 extracted from

  • Danielsson, K.; Rydberg, E.; Ingelsten, M.; Akyuerek, L.; Jirholt, P.; Ullstroem, C.; Forsberg, G.; Boren, J.; Wiklund, O.; Hulten, L.
    15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration (2008), Atherosclerosis, 199, 34-40.
    View publication on PubMed
Search for more literature for 1.13.11.33

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of 15-LOX-2 in human macrophages by adenovirus-mediated gene delivery Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA knockdown of 15-LOX-2 expression, decreases chemokine ligand CXCL10 secretion from hypoxic macrophages and reduces T cell migration and CD69 expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase-2
-
 Homo sapiens
15-LOX-2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function macrophages that overexpress 15-LOX-2 show increased secretion of chemokine ligands CXCL10 and CCL2 after 24h incubation. Preconditioned medium from 15-LOX-2-overexpressing cells increases T cell migration, the expression of T cell activation marker CD69 and surface expression of chemokine receptor CXCR3, the CXCL10 chemokine ligand. Increased expression of 15-LOX-2 induced by hypoxia may participate in T cell recruitment in diseases such as atherosclerosis Homo sapiens