Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | linoleic acid induces 15-LO-1 expression 2.6fold | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
conjugated linoleic acids | conjugated linoleic acids may function as inhibitors of 15-LO-1 activity in macrophages/in vivo, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | - |
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme 15-LO-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | isozyme 15-LO-1, differentiated monocytes obtained from human venous blood, CD14+ | Homo sapiens | - |
THP-1 cell | CD14+ | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
additional information | conjugated linoleic acids are no substrates for 15-LO-1 in vitro, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase | - |
Homo sapiens |
15-LO | - |
Homo sapiens |