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Literature summary for 1.13.11.33 extracted from

  • Weinstein, D.S.; Liu, W.; Gu, Z.; Langevine, C.; Ngu, K.; Fadnis, L.; Combs, D.W.; Sitkoff, D.; Ahmad, S.; Zhuang, S.; Chen, X.; Wang, F.L.; Loughney, D.A.; Atwal, K.S.; Zahler, R.; Macor, J.E.; Madsen, C.S.; Murugesan, N.
    Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase (2005), Bioorg. Med. Chem. Lett., 15, 1435-1440.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(-)-jaspic acid IC50: 0.0014 mM Oryctolagus cuniculus
2-(1H-indol-3-yl)-N-[(4-pentylphenyl)sulfonyl]acetamide
-
Oryctolagus cuniculus
2-[2-(1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
-
Oryctolagus cuniculus
2-[2-(2-bromo-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
-
Oryctolagus cuniculus
2-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-1H-isoindole-1,3(2H)-dione
-
Oryctolagus cuniculus
2-[3-(1H-indol-3-yl)propyl]-1H-isoindole-1,3(2H)-dione
-
Oryctolagus cuniculus
3-(2-[[(4-pentylphenyl)sulfonyl]amino]ethyl)-1H-indole-6-carboxylic acid
-
Oryctolagus cuniculus
3-[1-[(4-pentylphenyl)sulfonyl]pyrrolidin-3-yl]-1H-indole
-
Oryctolagus cuniculus
4'-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide IC50: 0.00053 mM in the presence of arachidonate, IC50: 0.0002 mM in the presence of linoleic acid Oryctolagus cuniculus
4'-ethyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide IC50: 0.00026 mM in the presence of arachidonate, IC50: 0.00047 mM in the presence of linoleic acid Oryctolagus cuniculus
4'-tert-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide IC50: 0.00027 mM in the presence of arachidonate, IC50: 0.00023 mM in the presence of linoleic acid Oryctolagus cuniculus
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-(3-hydroxypropyl)benzamide
-
Oryctolagus cuniculus
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-(4-methoxyphenyl)benzamide
-
Oryctolagus cuniculus
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-butylbenzamide
-
Oryctolagus cuniculus
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-cyclohexylbenzamide
-
Oryctolagus cuniculus
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-phenylbenzamide
-
Oryctolagus cuniculus
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-[3-(dimethylamino)propyl]benzamide
-
Oryctolagus cuniculus
4-([2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]sulfamoyl)benzoic acid
-
Oryctolagus cuniculus
4-bromo-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide
-
Oryctolagus cuniculus
4-butyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide IC50: 0.00307 mM in the presence of arachidonate, IC50: 0.004 mM in the presence of linoleic acid Oryctolagus cuniculus
4-butyl-N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]benzenesulfonamide
-
Oryctolagus cuniculus
4-ethyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid Oryctolagus cuniculus
4-pentyl-N-(2-[2-[4-(trifluoromethyl)phenyl]-1H-indol-3-yl]ethyl)benzenesulfonamide
-
Oryctolagus cuniculus
4-pentyl-N-[2-(2-phenyl-1H-indol-3-yl)ethyl]benzenesulfonamide
-
Oryctolagus cuniculus
4-pentyl-N-[2-(2-quinolin-3-yl-1H-indol-3-yl)ethyl]benzenesulfonamide
-
Oryctolagus cuniculus
4-pentyl-N-[2-[5-(1H-pyrrol-2-yl)-1H-indol-3-yl]ethyl]benzenesulfonamide
-
Oryctolagus cuniculus
dansyl tryptamine IC50: 0.00373 mM Oryctolagus cuniculus
jaspaquinol IC50: 0.0003 mM Oryctolagus cuniculus
methyl 3-(2-[[(4-pentylphenyl)sulfonyl]amino]ethyl)-1H-indole-6-carboxylate
-
Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)-1-methylethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-2'-methylbiphenyl-4-sulfonamide IC50: 0.00092 mM in the presence of arachidonate, IC50: 0.00046 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-3'-methylbiphenyl-4-sulfonamide IC50: 0.00045 mM in the presence of arachidonate, IC50: 0.00032 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4'-(1-methylethyl)biphenyl-4-sulfonamide IC50: 0.00028 mM in the presence of arachidonate, IC50: 0.00014 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4'-(2-methylpropyl)biphenyl-4-sulfonamide IC50: 0.00091 mM in the presence of arachidonate, IC50: 0.00017 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4'-methoxybiphenyl-4-sulfonamide IC50: 0.0015 mM in the presence of arachidonate, IC50: 0.00109 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4'-methylbiphenyl-4-sulfonamide IC50: 0.00047 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide IC50: 0.00042 mM in the presence of arachidonate, IC50: 0.00102 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-4-propylbenzenesulfonamide IC50: 0.00313 mM in the presence of arachidonate, IC50: 0.0032 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]-N-methyl-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide IC50: 0.0034 mM in the presence of arachidonate, IC50: 0.0042 mM in the presence of linoleic acid Oryctolagus cuniculus
N-[2-(2-dibenzo[b,d]furan-2-yl-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-(5-methyl-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-(7-methyl-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(1-benzofuran-2-yl)-1-methyl-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-(hydrazinocarbonyl)benzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-bromobenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-methylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-pyridin-4-ylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(2,5-dimethoxyphenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(4-chlorophenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(4-ethoxyphenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]-4-methylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]biphenyl-4-sulfonamide
-
Oryctolagus cuniculus
N-[3-(1H-indol-3-yl)propyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
N-[3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl]biphenyl-4-sulfonamide
-
Oryctolagus cuniculus
N-[4-(1H-indol-3-yl)butyl]-4-pentylbenzenesulfonamide
-
Oryctolagus cuniculus
nordihydroguaiaretic acid IC50: 0.00011 mM Oryctolagus cuniculus
PD-146176 IC50: 0.00381 mM Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
?
linoleic acid + O2
-
Oryctolagus cuniculus ?
-
?

Synonyms

Synonyms Comment Organism
15-lipoxygenase
-
Oryctolagus cuniculus
15-LO
-
Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00011
-
IC50: 0.00011 mM Oryctolagus cuniculus nordihydroguaiaretic acid
0.00014
-
IC50: 0.00028 mM in the presence of arachidonate, IC50: 0.00014 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4'-(1-methylethyl)biphenyl-4-sulfonamide
0.00017
-
IC50: 0.00091 mM in the presence of arachidonate, IC50: 0.00017 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4'-(2-methylpropyl)biphenyl-4-sulfonamide
0.0002
-
IC50: 0.00053 mM in the presence of arachidonate, IC50: 0.0002 mM in the presence of linoleic acid Oryctolagus cuniculus 4'-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide
0.00023
-
IC50: 0.00027 mM in the presence of arachidonate, IC50: 0.00023 mM in the presence of linoleic acid Oryctolagus cuniculus 4'-tert-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide
0.0003
-
IC50: 0.0003 mM Oryctolagus cuniculus jaspaquinol
0.00032
-
IC50: 0.00045 mM in the presence of arachidonate, IC50: 0.00032 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-3'-methylbiphenyl-4-sulfonamide
0.00046
-
IC50: 0.00092 mM in the presence of arachidonate, IC50: 0.00046 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-2'-methylbiphenyl-4-sulfonamide
0.00047
-
IC50: 0.00026 mM in the presence of arachidonate, IC50: 0.00047 mM in the presence of linoleic acid Oryctolagus cuniculus 4'-ethyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide
0.00047
-
IC50: 0.00047 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4'-methylbiphenyl-4-sulfonamide
0.00102
-
IC50: 0.00042 mM in the presence of arachidonate, IC50: 0.00102 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide
0.00109
-
IC50: 0.0015 mM in the presence of arachidonate, IC50: 0.00109 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4'-methoxybiphenyl-4-sulfonamide
0.0014
-
IC50: 0.0014 mM Oryctolagus cuniculus (-)-jaspic acid
0.0032
-
IC50: 0.00313 mM in the presence of arachidonate, IC50: 0.0032 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4-propylbenzenesulfonamide
0.00373
-
IC50: 0.00373 mM Oryctolagus cuniculus dansyl tryptamine
0.00381
-
IC50: 0.00381 mM Oryctolagus cuniculus PD-146176
0.004
-
IC50: 0.00307 mM in the presence of arachidonate, IC50: 0.004 mM in the presence of linoleic acid Oryctolagus cuniculus 4-butyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide
0.0042
-
IC50: 0.0034 mM in the presence of arachidonate, IC50: 0.0042 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide
0.01
-
IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid Oryctolagus cuniculus N-[2-(1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide
0.01
-
IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid Oryctolagus cuniculus 4-ethyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide