Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-jaspic acid | IC50: 0.0014 mM | Oryctolagus cuniculus | |
2-(1H-indol-3-yl)-N-[(4-pentylphenyl)sulfonyl]acetamide | - |
Oryctolagus cuniculus | |
2-[2-(1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione | - |
Oryctolagus cuniculus | |
2-[2-(2-bromo-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione | - |
Oryctolagus cuniculus | |
2-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-1H-isoindole-1,3(2H)-dione | - |
Oryctolagus cuniculus | |
2-[3-(1H-indol-3-yl)propyl]-1H-isoindole-1,3(2H)-dione | - |
Oryctolagus cuniculus | |
3-(2-[[(4-pentylphenyl)sulfonyl]amino]ethyl)-1H-indole-6-carboxylic acid | - |
Oryctolagus cuniculus | |
3-[1-[(4-pentylphenyl)sulfonyl]pyrrolidin-3-yl]-1H-indole | - |
Oryctolagus cuniculus | |
4'-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | IC50: 0.00053 mM in the presence of arachidonate, IC50: 0.0002 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
4'-ethyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | IC50: 0.00026 mM in the presence of arachidonate, IC50: 0.00047 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
4'-tert-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | IC50: 0.00027 mM in the presence of arachidonate, IC50: 0.00023 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-(3-hydroxypropyl)benzamide | - |
Oryctolagus cuniculus | |
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-(4-methoxyphenyl)benzamide | - |
Oryctolagus cuniculus | |
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-butylbenzamide | - |
Oryctolagus cuniculus | |
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-cyclohexylbenzamide | - |
Oryctolagus cuniculus | |
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-phenylbenzamide | - |
Oryctolagus cuniculus | |
4-([2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]sulfamoyl)-N-[3-(dimethylamino)propyl]benzamide | - |
Oryctolagus cuniculus | |
4-([2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]sulfamoyl)benzoic acid | - |
Oryctolagus cuniculus | |
4-bromo-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide | - |
Oryctolagus cuniculus | |
4-butyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide | IC50: 0.00307 mM in the presence of arachidonate, IC50: 0.004 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
4-butyl-N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]benzenesulfonamide | - |
Oryctolagus cuniculus | |
4-ethyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide | IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
4-pentyl-N-(2-[2-[4-(trifluoromethyl)phenyl]-1H-indol-3-yl]ethyl)benzenesulfonamide | - |
Oryctolagus cuniculus | |
4-pentyl-N-[2-(2-phenyl-1H-indol-3-yl)ethyl]benzenesulfonamide | - |
Oryctolagus cuniculus | |
4-pentyl-N-[2-(2-quinolin-3-yl-1H-indol-3-yl)ethyl]benzenesulfonamide | - |
Oryctolagus cuniculus | |
4-pentyl-N-[2-[5-(1H-pyrrol-2-yl)-1H-indol-3-yl]ethyl]benzenesulfonamide | - |
Oryctolagus cuniculus | |
dansyl tryptamine | IC50: 0.00373 mM | Oryctolagus cuniculus | |
jaspaquinol | IC50: 0.0003 mM | Oryctolagus cuniculus | |
methyl 3-(2-[[(4-pentylphenyl)sulfonyl]amino]ethyl)-1H-indole-6-carboxylate | - |
Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)-1-methylethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-2'-methylbiphenyl-4-sulfonamide | IC50: 0.00092 mM in the presence of arachidonate, IC50: 0.00046 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-3'-methylbiphenyl-4-sulfonamide | IC50: 0.00045 mM in the presence of arachidonate, IC50: 0.00032 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4'-(1-methylethyl)biphenyl-4-sulfonamide | IC50: 0.00028 mM in the presence of arachidonate, IC50: 0.00014 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4'-(2-methylpropyl)biphenyl-4-sulfonamide | IC50: 0.00091 mM in the presence of arachidonate, IC50: 0.00017 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4'-methoxybiphenyl-4-sulfonamide | IC50: 0.0015 mM in the presence of arachidonate, IC50: 0.00109 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4'-methylbiphenyl-4-sulfonamide | IC50: 0.00047 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide | IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | IC50: 0.00042 mM in the presence of arachidonate, IC50: 0.00102 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-4-propylbenzenesulfonamide | IC50: 0.00313 mM in the presence of arachidonate, IC50: 0.0032 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]-N-methyl-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | IC50: 0.0034 mM in the presence of arachidonate, IC50: 0.0042 mM in the presence of linoleic acid | Oryctolagus cuniculus | |
N-[2-(2-dibenzo[b,d]furan-2-yl-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-(5-methyl-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-(7-methyl-1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(1-benzofuran-2-yl)-1-methyl-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-(hydrazinocarbonyl)benzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-bromobenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl]-4-pyridin-4-ylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(2,5-dimethoxyphenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(4-chlorophenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(4-ethoxyphenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]-4-methylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl]biphenyl-4-sulfonamide | - |
Oryctolagus cuniculus | |
N-[3-(1H-indol-3-yl)propyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
N-[3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl]biphenyl-4-sulfonamide | - |
Oryctolagus cuniculus | |
N-[4-(1H-indol-3-yl)butyl]-4-pentylbenzenesulfonamide | - |
Oryctolagus cuniculus | |
nordihydroguaiaretic acid | IC50: 0.00011 mM | Oryctolagus cuniculus | |
PD-146176 | IC50: 0.00381 mM | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
reticulocyte | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Oryctolagus cuniculus | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
linoleic acid + O2 | - |
Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase | - |
Oryctolagus cuniculus |
15-LO | - |
Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00011 | - |
IC50: 0.00011 mM | Oryctolagus cuniculus | nordihydroguaiaretic acid | |
0.00014 | - |
IC50: 0.00028 mM in the presence of arachidonate, IC50: 0.00014 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4'-(1-methylethyl)biphenyl-4-sulfonamide | |
0.00017 | - |
IC50: 0.00091 mM in the presence of arachidonate, IC50: 0.00017 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4'-(2-methylpropyl)biphenyl-4-sulfonamide | |
0.0002 | - |
IC50: 0.00053 mM in the presence of arachidonate, IC50: 0.0002 mM in the presence of linoleic acid | Oryctolagus cuniculus | 4'-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | |
0.00023 | - |
IC50: 0.00027 mM in the presence of arachidonate, IC50: 0.00023 mM in the presence of linoleic acid | Oryctolagus cuniculus | 4'-tert-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | |
0.0003 | - |
IC50: 0.0003 mM | Oryctolagus cuniculus | jaspaquinol | |
0.00032 | - |
IC50: 0.00045 mM in the presence of arachidonate, IC50: 0.00032 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-3'-methylbiphenyl-4-sulfonamide | |
0.00046 | - |
IC50: 0.00092 mM in the presence of arachidonate, IC50: 0.00046 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-2'-methylbiphenyl-4-sulfonamide | |
0.00047 | - |
IC50: 0.00026 mM in the presence of arachidonate, IC50: 0.00047 mM in the presence of linoleic acid | Oryctolagus cuniculus | 4'-ethyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | |
0.00047 | - |
IC50: 0.00047 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4'-methylbiphenyl-4-sulfonamide | |
0.00102 | - |
IC50: 0.00042 mM in the presence of arachidonate, IC50: 0.00102 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide | |
0.00109 | - |
IC50: 0.0015 mM in the presence of arachidonate, IC50: 0.00109 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4'-methoxybiphenyl-4-sulfonamide | |
0.0014 | - |
IC50: 0.0014 mM | Oryctolagus cuniculus | (-)-jaspic acid | |
0.0032 | - |
IC50: 0.00313 mM in the presence of arachidonate, IC50: 0.0032 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4-propylbenzenesulfonamide | |
0.00373 | - |
IC50: 0.00373 mM | Oryctolagus cuniculus | dansyl tryptamine | |
0.00381 | - |
IC50: 0.00381 mM | Oryctolagus cuniculus | PD-146176 | |
0.004 | - |
IC50: 0.00307 mM in the presence of arachidonate, IC50: 0.004 mM in the presence of linoleic acid | Oryctolagus cuniculus | 4-butyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide | |
0.0042 | - |
IC50: 0.0034 mM in the presence of arachidonate, IC50: 0.0042 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide | |
0.01 | - |
IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid | Oryctolagus cuniculus | N-[2-(1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide | |
0.01 | - |
IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid | Oryctolagus cuniculus | 4-ethyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide |