Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine | - |
Homo sapiens | |
adamantyl caffeate | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.074 mM | Homo sapiens | |
bornyl vanillate | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.401 mM | Homo sapiens | |
fenchyl caffeate | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.089 mM | Homo sapiens | |
additional information | stylosin and some similar synthetic monoterpenoids show inhibitory effects on 15-LOX. A strong positive correlation is observed between 15-LOX inhibition potential and cytotoxicity of the compounds with apoptosis being the predominant mechanism of induced cell death | Homo sapiens | |
stylosin | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.101 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16050 | cf. EC 1.13.11.12, EC 1.13.11.33 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
linoleate + O2 | - |
Homo sapiens | (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-LOX-1 | - |
Homo sapiens |
Alox15 | - |
Homo sapiens |