Literature summary for 1.13.11.31 extracted from

Adams, W.; Bhowmick, R.; Bou Ghanem, E.N.; Wade, K.; Shchepetov, M.; Weiser, J.N.; McCormick, B.A.; Tweten, R.K.; Leong, J.M.
Pneumolysin induces 12-lipoxygenase-dependent neutrophil migration during Streptococcus pneumoniae infection (2020), J. Immunol., 204, 101-111 .

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Application

Application	Comment	Organism
medicine	Streptococcus pneumoniae infection of the respiratory epithelium induces the production of the 12-lipoxygenase-dependent lipid inflammatory mediator hepoxilin A3, which promotes recruitment of neutrophils into the airways, tissue damage, and lethal septicemia. A pneumolysin-deficient S. pneumoniae mutant is impaired in triggering human neutrophil transepithelial migration in vitro	Homo sapiens
medicine	Streptococcus pneumoniae infection of the respiratory epithelium induces the production of the 12-lipoxygenase-dependent lipid inflammatory mediator hepoxilin A3, which promotes recruitment of neutrophils into the airways, tissue damage, and lethal septicemia. A pneumolysin-deficient S. pneumoniae mutant is impaired in triggering human neutrophil transepithelial migration in vitro	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	P55249	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Mus musculus	-
NCI-H292 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
12-LOX	-	Homo sapiens
12-LOX	-	Mus musculus
Alox15	-	Homo sapiens

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Release 2023.1 (January 2023)