Literature summary for 1.13.11.31 extracted from

Freedman, C.; Tran, A.; Tourdot, B.E.; Kalyanaraman, C.; Perry, S.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Biosynthesis of the maresin intermediate, 13S,14S-epoxy-DHA, by human 15-lipoxygenase and 12-lipoxygenase and its regulation through negative allosteric modulators (2020), Biochemistry, 59, 1832-1844 .

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0009	-	4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	pH 7.5, 25°C	Homo sapiens
0.00095	-	arachidonate	pH 7.5, 25°C	Homo sapiens
0.0027	-	arachidonate	pH 7.5, 25°C	Homo sapiens
0.0067	-	4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	pH 7.5, 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16050	cf. EC 1.13.11.33	-
Homo sapiens	P18054	isoform Alox 12, cf. EC 1.13.11.33	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(14S)-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid + ?	-	Homo sapiens	(13S,14S)-epoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	-	?
4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid + O2	-	Homo sapiens	(11S)-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid + (14S)-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid + (17S)-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	-	?
arachidonate + O2	-	Homo sapiens	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
ALOX12	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
2.4	-	4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	pH 7.5, 25°C	Homo sapiens
5.3	-	arachidonate	pH 7.5, 25°C	Homo sapiens
13	-	4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	pH 7.5, 25°C	Homo sapiens
18	-	arachidonate	pH 7.5, 25°C	Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
360	-	4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	pH 7.5, 25°C	Homo sapiens
2000	-	arachidonate	pH 7.5, 25°C	Homo sapiens
14000	-	4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid	pH 7.5, 25°C	Homo sapiens
19000	-	arachidonate	pH 7.5, 25°C	Homo sapiens

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Release 2023.1 (January 2023)