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Literature summary for 1.13.11.31 extracted from

  • Lieb, D.C.; Brotman, J.J.; Hatcher, M.A.; Aye, M.S.; Cole, B.K.; Haynes, B.A.; Wohlgemuth, S.D.; Fontana, M.A.; Beydoun, H.; Nadler, J.L.; Dobrian, A.D.
    Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes (2014), J. Clin. Endocrinol. Metab., 99, E1713-E1720 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine selective ALOX 12 inhibitors may constitute a good approach to limit adipose tissue inflammation in human obesity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens
-
 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16050
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue visceral, gene ALOX12 expression positively correlated with expression of inflammatory genes encoding IL-6, IL-12a, CXCL10, and lipocalin-2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
12/15 lipoxygenase
-
 Homo sapiens
ALOX 12
-
 Homo sapiens
ALOX 12/15
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ALOX12 expression and its metabolite 12(S)-hydroxyeicosatetraenoic acid are significantly increased in the visceral adipose tissue of type 2 diabetes subjects with body mass index of 21. ALOX12 expression positively correlated with expression of inflammatory genes encoding IL-6, IL-12a, CXCL10, and lipocalin-2 up

General Information

General Information Comment Organism
malfunction ALOX12 expression and its metabolite 12(S)-hydroxyeicosatetraenoic acid are significantly increased in the visceral adipose tissue of type 2 diabetes subjects with body mass index of 21 Homo sapiens
physiological function ALOX12 may have a critical role in regulation of inflammation in visceral adipose tissue in obesity and type 2 diabetes. Visceral adipose tissue (VAT) is a key contributor to chronic inflammation in obesity. The 12/15-lipoxygenase pathway (ALOX) is present in adipose tissue (AT) and leads to inflammatory cascades that are causal for the onset of insulin resistance in rodent models of obesity Homo sapiens