Application | Comment | Organism |
---|---|---|
medicine | selective ALOX 12 inhibitors may constitute a good approach to limit adipose tissue inflammation in human obesity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16050 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | visceral, gene ALOX12 expression positively correlated with expression of inflammatory genes encoding IL-6, IL-12a, CXCL10, and lipocalin-2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12/15 lipoxygenase | - |
Homo sapiens |
ALOX 12 | - |
Homo sapiens |
ALOX 12/15 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ALOX12 expression and its metabolite 12(S)-hydroxyeicosatetraenoic acid are significantly increased in the visceral adipose tissue of type 2 diabetes subjects with body mass index of 21. ALOX12 expression positively correlated with expression of inflammatory genes encoding IL-6, IL-12a, CXCL10, and lipocalin-2 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | ALOX12 expression and its metabolite 12(S)-hydroxyeicosatetraenoic acid are significantly increased in the visceral adipose tissue of type 2 diabetes subjects with body mass index of 21 | Homo sapiens |
physiological function | ALOX12 may have a critical role in regulation of inflammation in visceral adipose tissue in obesity and type 2 diabetes. Visceral adipose tissue (VAT) is a key contributor to chronic inflammation in obesity. The 12/15-lipoxygenase pathway (ALOX) is present in adipose tissue (AT) and leads to inflammatory cascades that are causal for the onset of insulin resistance in rodent models of obesity | Homo sapiens |