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Literature summary for 1.13.11.31 extracted from

  • Dilly, A.K.; Ekambaram, P.; Guo, Y.; Cai, Y.; Tucker, S.C.; Fridman, R.; Kandouz, M.; Honn, K.V.
    Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/Akt/NF-kappaB (2013), Int. J. Cancer, 133, 1784-1791.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
baicalein inhibition of 12-LOX enzymatic activity using baicalein inhibits MMP9 expression in PC3 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
12-LOX
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction 12-LOX-overexpressing PC-3 cells show an enhanced invasive ability which results from an increase in MMP9 expression and secretion Homo sapiens
physiological function 12-LOX mediates the MMP9 secretion via activation of PI3K/Akt/NF-kappaB Homo sapiens