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Literature summary for 1.13.11.31 extracted from

  • Nagelin, M.H.; Srinivasan, S.; Nadler, J.L.; Hedrick, C.C.
    Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways (2009), J. Biol. Chem., 284, 31303-31314.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.31

Cloned(Commentary)

Cloned (Comment) Organism
full-length cDNA for 12/15LO subcloned into vector pACCMVpLpA. Bone marrow-derived macrophages infected at a multiplicity of infection of 50 for 48 h with recombinant adenoviral vector AdLO to overexpress 12/15LO Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P39654
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage macrophages that overexpress 12/15LO have reduced ATP-binding cassette G1 expression, increased transporter phosphorylation, and reduced cholesterol efflux Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
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 Mus musculus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
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 ?

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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 Mus musculus
12/15LO
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 Mus musculus

General Information

General Information Comment Organism
malfunction macrophages that lack 12/15LO have enhanced transporter expression, reduced ATP-binding cassette G1 phosphorylation, and increased cholesterol efflux Mus musculus
physiological function 12/15LO plays a key role in activating the mitogen-activated protein kinase pathway. 12/15LO regulates ATP-binding cassette G1 expression and function through p38- and c-Jun N-terminal kinase 2-dependent mechanisms Mus musculus