Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-oxapentadeca-4-yne)phenylpropanoic acid | mixed type inhibition towards the ferric form of 12-lipoxygenase | Sus scrofa | |
5,8,11,14-Eicosatetraynoic acid | - |
Sus scrofa | |
BWA137C | - |
Sus scrofa | |
N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea | - |
Sus scrofa | |
nordihydroguaiaretic acid | - |
Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | enzyme contains iron | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid | Sus scrofa | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
4-(2-oxapentadeca-4-yne)phenylpropanoic acid | inhibition of the ferric form of 12-lipoxygenase, free enzyme | Sus scrofa | |
0.0045 | - |
4-(2-oxapentadeca-4-yne)phenylpropanoic acid | inhibition of the ferric form of 12-lipoxygenase, substrate-bound form of enzyme | Sus scrofa | |
0.07 | - |
4-(2-oxapentadeca-4-yne)phenylpropanoic acid | inhibition of the ferrous form of 12-lipoxygenase | Sus scrofa |