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Literature summary for 1.13.11.31 extracted from
- Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid (1982), Biochim. Biophys. Acta, 713, 638-646.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,8,11,14-Eicosatetraynoic acid | 0.01 mM, 86% inhibition | Sus scrofa |  |
| arachidonic acid | inhibits reaction with 5-hydroxy-6,8,11,14-eicodatetraenoic acid | Sus scrofa | |
| BW755C | 0.01 mM, 72% inhibition | Sus scrofa | |
| nordihydroguaiaretic acid | 0.01 mM, 97% inhibition | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0045 | - |
5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid | - |
Sus scrofa | |
| 0.0066 | - |
arachidonic acid | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Sus scrofa | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | polymorphonuclear | Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid + O2 | 40% of the activity with arachidonic acid | Sus scrofa | 5,12-(5S,12S)-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5,12-(5S,15S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid | - |
? | |
| 5,8,11,14,17-eicosapentaenoic acid + O2 | 14% of the activity with arachidonic acid | Sus scrofa | 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid | - |
? | |
| 8,11,14-eicosatrienoic acid + O2 | 95% of the activity with arachidonic acid | Sus scrofa | 12-hydroxyeicosatrienoic acid | - |
? | |
| arachidonate + O2 | i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid | Sus scrofa | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Sus scrofa |
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