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Literature summary for 1.13.11.3 extracted from

  • Sainsbury, P.D.; Mineyeva, Y.; Mycroft, Z.; Bugg, T.D.
    Chemical intervention in bacterial lignin degradation pathways development of selective inhibitors for intradiol and extradiol catechol dioxygenases (2015), Bioorg. Chem., 60, 102-109 .
    View publication on PubMed
Search for more literature for 1.13.11.3

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-(3,4-dimethoxyphenyl)-N-hydroxyprop-2-enamide over 90% inhibition at 0.2 mM Rhodococcus jostii
(2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide over 90% inhibition at 0.2 mM Rhodococcus jostii
2-(2H-1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide 60% inhibition at 0.2 mM Rhodococcus jostii
3-(3,4-dimethoxyphenyl)-N-hydroxy-N-octylpropanamide 57% inhibition at 0.2 mM Rhodococcus jostii
3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide 60% inhibition at 0.2 mM Rhodococcus jostii
additional information poor inhibition by N-hydroxy-3-(4-methoxyphenyl)propanamide at 0.2 mM Rhodococcus jostii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-dihydroxybenzoate + O2 Rhodococcus jostii
-
 3-carboxy-cis,cis-muconate
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodococcus jostii Q0SH27 AND Q0SH26 beta- and alpha-subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxybenzoate + O2
-
 Rhodococcus jostii 3-carboxy-cis,cis-muconate
-
 ?

Synonyms

Synonyms Comment Organism
3,4-PCD
-
 Rhodococcus jostii
protocatechuate 3,4-dioxygenase
-
 Rhodococcus jostii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rhodococcus jostii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rhodococcus jostii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
 pH 7.5, 37°C Rhodococcus jostii (2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide
0.02
-
 pH 7.5, 37°C Rhodococcus jostii (2E)-3-(3,4-dimethoxyphenyl)-N-hydroxyprop-2-enamide
0.16
-
 pH 7.5, 37°C Rhodococcus jostii 3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide