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Literature summary for 1.13.11.27 extracted from

  • Kavana, M.; Moran, G.R.
    Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione (2003), Biochemistry, 42, 10238-10245.
    View publication on PubMed

Application

Application Comment Organism
medicine mechanism of binding of the inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione used to treat type I tyrosinemia. Enzyme-Fe(II)-inhibitor complex does not oxidize, dissociation rate constant is essentially zero Streptomyces avermitilis

Inhibitors

Inhibitors Comment Organism Structure
2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione mechanism of binding, enzyme-Fe(II)-inhibitor complex does not oxidize, dissociation rate constant is essentially zero Streptomyces avermitilis

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
Streptomyces avermitilis

Organism

Organism UniProt Comment Textmining
Streptomyces avermitilis
-
-
-