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Literature summary for 1.13.11.27 extracted from

  • Aarenstrup, L.; Falch, A.M.; Jakobsen, K.K.; Neve, S.; Henriksen, L.L.; Tommerup, N.; Leffers, H.; Kristiansen, K.
    Expression and post-translational modification of human 4-hydroxy-phenylpyruvate dioxygenase (2002), Cell Biol. Int., 26, 615-625.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
vaccinia virus-based expression in human AMA cells and expression in Escherichia coli Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylpyruvate + O2 Homo sapiens key enzyme involved in tyrosine catabolism, congenital 4-hydroxyphenylpyruvate dioxygenase deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia homogentisate + CO2
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein recombinant enzyme can be phosphorylated in human AMA cells, phosphorylation is not indispensable for activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylpyruvate + O2
-
Homo sapiens homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2 key enzyme involved in tyrosine catabolism, congenital 4-hydroxyphenylpyruvate dioxygenase deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia Homo sapiens homogentisate + CO2
-
?