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Literature summary for 1.13.11.27 extracted from
- Multiple forms of human 4-hydroxyphenylpyruvate dioxygenase (II) (1977), J. Biol. Chem., 252, 5085-5093.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxyphenylpyruvate | enzyme form 2 and 3, no substrate inhibition is observed for enzyme form 1 | Homo sapiens |  |
| bathophenanthroline | - |
Homo sapiens | |
| diethyldithiocarbamate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
4-hydroxyphenylpyruvate | enzyme form 1 | Homo sapiens | |
| 0.027 | - |
4-hydroxyphenylpyruvate | enzyme form 2 | Homo sapiens | |
| 0.029 | - |
4-hydroxyphenylpyruvate | enzyme form 3 | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 63000 | 67000 | enzyme forms 1, 2, and 3, gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
enzyme form 1, 2, and 3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.51 | 1.1 | enzyme forms 1, 2, and 3 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylpyruvate + O2 | - |
Homo sapiens | homogentisate + CO2 | - |
? | |
| phenylpyruvate + O2 | - |
Homo sapiens | 2-hydroxyphenylacetate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the multiple enzyme forms are not interconvertible by oxidation, reduction, pyridine inactivation, metal chelator treatment, or treatment with neuraminidase | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.6 | - |
and a second optimum at pH 7.4, enzyme form 3 | Homo sapiens |
| 5.1 | - |
and a second optimum at pH 7.4, enzyme form 1 and 2 | Homo sapiens |
| 7.4 | - |
and a second optimum at pH 5.1 for enzyme form 1 and 2, and at pH 4.6 for enzyme form 3 | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
4-hydroxyphenylpyruvate | about, enzyme form 3 | Homo sapiens | |
| 0.7 | - |
4-hydroxyphenylpyruvate | about, enzyme form 2 | Homo sapiens | |
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