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Literature summary for 1.13.11.27 extracted from

  • Fellmann, J.H.
    4-Hydroxyphenylpyruvate dioxygenase from avian liver (1987), Methods Enzymol., 142, 148-154.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Gallus gallus
1-(2'-thionyl)-3,3,3-trifluoroacetone
-
Gallus gallus
2,2'-bipyridyl
-
Gallus gallus
2,4-Dihydroxyphenylpyruvate competitive Gallus gallus
2-Hydroxybenzaldehyde competitive Gallus gallus
2-Hydroxyphenylpyruvate competitive Gallus gallus
3-hydroxyphenylpyruvate competitive Gallus gallus
3-methoxy-4-hydroxyphenylpyruvate competitive Gallus gallus
bathophenanthroline
-
Gallus gallus
Cupferron
-
Gallus gallus
diethyldithiocarbamate
-
Gallus gallus
Dithizone
-
Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron 0.88 mol of iron per mol of enzyme Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
49000
-
2 * 49000, SDS-PAGE Gallus gallus
97000
-
equilibrium sedimentation Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.5
-
-
Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylpyruvate + O2
-
Gallus gallus ? + CO2
-
?
4-fluorophenylpyruvate + O2
-
Gallus gallus 4-fluoro-2-hydroxyphenylacetate + CO2
-
?
4-hydroxyphenylpyruvate + O2
-
Gallus gallus homogentisate + CO2
-
?
4-methylphenylpyruvate + O2 poor substrate Gallus gallus ? + CO2
-
?
phenylpyruvate + O2
-
Gallus gallus 2-hydroxyphenylacetate + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 49000, SDS-PAGE Gallus gallus