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Literature summary for 1.13.11.20 extracted from

  • Song, Z.; Yue, Y.; Feng, S.; Sun, H.; Li, Y.; Xu, F.; Zhang, Q.; Wang, W.
    Cysteine dioxygenase catalyzed C-F bond cleavage An in silico approach (2020), Chem. Phys. Lett., 750, 137449 .
No PubMed abstract available
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Application

Application Comment Organism
synthesis the mechanism of cysteine dioxygenase-catalyzed C-F bond cleavage of 3,5-difluoro-1-tyrosine contains four elementary steps: H-abstraction, C-S bond formation, F-transfer, and C-F bond cleavage. C-F bond cleavage is the rate-determining step with an energy barrier of 18.8 kcal/mol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16878
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is able to cleave C-F bonds. The oxidants produced at the center of the non-heme ferrite effectively oxidize adjacent coordination residues and oxidize C-Cl and even C-F bonds during the formation of dihalogen-substituted cofactors, via four elementary steps: H-abstraction, C-S bond formation, F-transfer, and C-F bond cleavage. C-F bond cleavage is the rate-determining step with an energy barrier of 18.8 kcal/mol Homo sapiens ?
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