Literature summary for 1.13.11.20 extracted from

Che, X.; Gao, J.; Liu, Y.; Liu, C.
Metal vs. chalcogen competition in the catalytic mechanism of cysteine dioxygenase (2013), J. Inorg. Biochem., 122, 1-7.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	required for catalysis, in the Cys-bound complexes, the change of the oxidation state for the Fe center is II to III to II. Binding involves coordination with His86, His88, and His140	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	cysteine dioxygenase cannot catalyze the oxidation of selenocysteine. In the Cys-bound complexes, the change of the oxidation state for the Fe center is II to III to II, while the Fe center in the Sec-bound complexes remains in the II oxidation state throughout. The competition for donation of electron density with the iron ion determines the valence change and the reaction ability	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
CDO	-	Rattus norvegicus

General Information

General Information	Comment	Organism
additional information	structures of iron-containing CDO model complexes, modeling, overview	Rattus norvegicus

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Release 2023.1 (January 2023)