Cloned (Comment) | Organism |
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expression in Escherichia coli and HepG2/C3A cell | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | P21816 | - |
- |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme uses an amino acid cofactor in the active site consisting of two cross-linked residues, cysteine 93 and tyrosine 157. Formation of the Cys-Tyr cofactor requires a transition metal cofactor Fe2+ and O2. Biogenesis of the cofactor is also strictly dependent upon the presence of substrate. In the absence of the Cys-Tyr cofactor, the enzyme possesses appreciable catalytic activity. At physiologically relevant cysteine concentrations, cofactor formation increases catalytic efficiency 10-fold | Rattus norvegicus |