Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.20 extracted from

  • Yamaguchi, K.; Hosokawa, Y.
    Cysteine dioxygenase (1987), Methods Enzymol., 143, 395-403.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Carboxyethyl-L-cysteine at 10 mM, activation Rattus norvegicus
carboxymethyl-L-cysteine at 10 mM, activation Rattus norvegicus
cysteamine at 100 mM, activation Rattus norvegicus
D-cysteine at 10 mM, activation Rattus norvegicus
DL-homocysteine at 100 mM, slight activation Rattus norvegicus
hydrocortisone induces Rattus norvegicus
methionine induces Rattus norvegicus
N-acetyl-L-cysteine at 100 mM, slight activation Rattus norvegicus
NAD(P)H stimulation Rattus norvegicus
S-methyl-L-cysteine at 10 mM, activation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Carboxyethyl-L-cysteine 53% inhibition at 1 mM Rattus norvegicus
carboxymethyl-L-cysteine 37% inhibition at 1 mM Rattus norvegicus
cysteamine 39% inhibition at 10 mM Rattus norvegicus
D-cysteine inhibition at 1 mM Rattus norvegicus
DL-homocysteine
-
Rattus norvegicus
N-acetyl-L-cysteine 35% inhibition at 10 mM Rattus norvegicus
S-methyl-L-cysteine 34% inhibition at 1 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.45
-
cysteine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe Fe2+ required, 0.8-0.9 gatom of iron per 22500 g of purified protein Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22500
-
SDS-PAGE, gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Oxidation Stability

Oxidation Stability Organism
rapid and irreversible inactivation under aerobic conditions, inactivation can be prevented by a distinct cytoplasmic protein, i.e. protein A Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
using acetone fractionation, column chromatography on DEAE-cellulose, Sephadex G-100, hydroxylapatite, DEAE-Sephadex A-25 and Sephadex G-75 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
0°C, no significant loss of activity after 1 month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + O2 highly specific for L-cysteine Rattus norvegicus 3-sulfino-L-alanine
-
?
additional information L-cystine, D-cysteine, carboxymethyl-L-cysteine, carboxyethyl-L-cysteine, S-methyl-L-cysteine, N-acetyl-L-cysteine, DL-homocysteine and cysteamine do not serve as substrates Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 22500, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus