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Literature summary for 1.13.11.19 extracted from

  • Liu, C.L.; Watson, A.M.; Place, A.R.; Jagus, R.
    Taurine biosynthesis in a fish liver cell line (ZFL) adapted to a serum-free medium (2017), Mar. Drugs, 15, 147-161 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.19

Cloned(Commentary)

Cloned (Comment) Organism
relative expression level determination in cells grown in taurin-free or taurine-containing medium, overview Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-aminoethanethiol + O2 Danio rerio
-
 hypotaurine
-
 ?
2-aminoethanethiol + O2 Danio rerio ATCC CRL-2643
-
 hypotaurine
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Danio rerio ATCC CRL-2643
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture grown in taurin-free or taurine-containing medium Danio rerio
-
hepatocyte
-
 Danio rerio
-
liver
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminoethanethiol + O2
-
 Danio rerio hypotaurine
-
 ?
2-aminoethanethiol + O2
-
 Danio rerio ATCC CRL-2643 hypotaurine
-
 ?

Synonyms

Synonyms Comment Organism
2-aminoethanethiol dioxygenase
-
 Danio rerio
ADO
-
 Danio rerio

Expression

Organism Comment Expression
Danio rerio addition of taurine to cells grown in taurine-free medium has little effect on transcript levels of the biosynthetic pathway genes for cysteine dioxygenase (CDO), cysteine sulfinate decarboxylase (CSAD), or cysteamine dioxygenase (ADO). In contrast, supplementation with taurine causes a 30% reduction in transcript levels of the taurine transporter, TauT additional information

General Information

General Information Comment Organism
metabolism the enzyme is involved in the taurine biosynthetic pathway. addition of taurine to cells grown in taurine-free medium has little effect on transcript levels of the biosynthetic pathway genes for cysteine dioxygenase (CDO), cysteine sulfinate decarboxylase (CSAD), or cysteamine dioxygenase (ADO). In contrast, supplementation with taurine causes a 30% reduction in transcript levels of the taurine transporter, TauT. Hypotaurine can be produced via of cysteamine, the end product of coenzyme A degradation, via oxidation by 2-aminoethanethiol dioxygenase (ADO). Taurine biosynthetic pathway from methionine?derived cysteine, overview Danio rerio