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Literature summary for 1.13.11.15 extracted from
- The homogentisate and homoprotocatechuate central pathways are involved in 3- and 4-hydroxyphenylacetate degradation by Burkholderia xenovorans LB400 (2011), PLoS ONE, 6, e17583.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene hpaD, gene cluster hpaG1G2EDFHI encodes the homoprotocatechuate pathway is located at C2 in strain LB400 genome, quantitative expression analysis | Paraburkholderia xenovorans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenylacetate + O2 | Paraburkholderia xenovorans | - |
2-hydroxy-5-carboxymethylmuconate semialdehyde | - |
? |  |
| additional information | Paraburkholderia xenovorans | LB400 cells grown with 3-hydroxyphenylacetate degrade homoprotocatechuate and show homoprotocatechuate 2,3-dioxygenase activity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paraburkholderia xenovorans | - |
gene hpaD | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| culture condition:3-hydroxyphenylacetate-grown cell | - |
Paraburkholderia xenovorans | - |
| culture condition:4-hydroxyphenylacetate-grown cell | - |
Paraburkholderia xenovorans | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenylacetate + O2 | - |
Paraburkholderia xenovorans | 2-hydroxy-5-carboxymethylmuconate semialdehyde | - |
? | |
| additional information | LB400 cells grown with 3-hydroxyphenylacetate degrade homoprotocatechuate and show homoprotocatechuate 2,3-dioxygenase activity | Paraburkholderia xenovorans | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| homoprotocatechuate 2,3-dioxygenase | - |
Paraburkholderia xenovorans |
| HPC 2,3-dioxygenase | - |
Paraburkholderia xenovorans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Paraburkholderia xenovorans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Paraburkholderia xenovorans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Paraburkholderia xenovorans | induction of fumarylacetoacetate hydrolase HmgB in Burkholderia xenovorans LB400 during growth on hydroxyphenylacetates | additional information |
| Paraburkholderia xenovorans | LB400 cells grown with 3-hydroxyphenylacetate and 4-hydroxyphenylacetate both show induction of the homoprotocatechuate pathway, they degrade homoprotocatechuate and show homoprotocatechuate 2,3-dioxygenase activity. The hmgA1 gene is upregulated by 3-hydroxyphenylacetate in strain LB400. The expression of the hpaD gene, encoding HPC 2,3-dioxygenase, is induced in 3-hydroxyphenylacetate and 4-hydroxyphenylacetate grown-cells | up |
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