Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',4,6-trimethoxy-aurone | - |
Glycine max | |
2'-hydroxy-2,4',6'-trimethoxy-chalcone | exhibits 20% inhibition | Glycine max | |
2'-hydroxy-2-methoxy-chalcone | - |
Glycine max | |
2'-hydroxy-3,4,4',6'-tetra(methoxymethoxy)-chalcone | exhibits 14.1% inhibition | Glycine max | |
2'-hydroxy-3,4-dimethoxy-chalcone | - |
Glycine max | |
2'-hydroxy-3-methoxy-chalcone | exhibits 36.4% inhibition | Glycine max | |
2'-hydroxy-4-chloro-4', 6'-dimethoxy-chalcone | - |
Glycine max | |
2'-hydroxy-4-chloro-chalcone | - |
Glycine max | |
2'-hydroxy-4-methyl-4',6'-dimethoxy-chalcone | - |
Glycine max | |
2'-hydroxy-4-methyl-chalcone | - |
Glycine max | |
2'-methoxy-aurone | exhibits 39.9% inhibition | Glycine max | |
3'-methoxy-aurone | exhibits 34.9% inhibition | Glycine max | |
4'-chloro-4, 6-dimethoxy-aurone | - |
Glycine max | |
4'-chloro-aurone | exhibits 26.4% inhibition | Glycine max | |
4'-methoxy-aurone | - |
Glycine max | |
4'-methyl-aurone | exhibits 32.4% inhibition | Glycine max | |
4,4',6-trimethoxy-aurone | best LOX inhibitory activity | Glycine max | |
caffeic acid | - |
Glycine max | |
additional information | chalcones exhibit superior LOX inhibitory activity than aurones. 2'-hydroxy-4-methoxy-chalcone, 2'-hydroxy-3,4,4',6'-tetramethoxy-chalcone, 2'-hydroxy-4,4',6'-trimethoxy-chalcone, 2',3,4,4',6'-pentahydroxy-chalcone, aureusidin, 4,6-dimethoxy-4'-methyl-aurone and 3',4,4',6-tetra(methoxymethyl)-aurone have no or very low LOX inhibitory activity | Glycine max | |
nordihydroguaiaretic acid | - |
Glycine max |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Glycine max | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
linoleate + O2 | - |
Glycine max | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Glycine max |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Glycine max |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.04 | - |
at pH 9.0 | Glycine max | nordihydroguaiaretic acid | |
0.05 | - |
at pH 9.0 | Glycine max | 4,4',6-trimethoxy-aurone | |
0.0525 | - |
at pH 9.0 | Glycine max | 2'-hydroxy-4-methyl-chalcone | |
0.053 | - |
at pH 9.0 | Glycine max | 2'-hydroxy-4-methyl-4',6'-dimethoxy-chalcone | |
0.056 | - |
at pH 9.0 | Glycine max | 2'-hydroxy-4-chloro-chalcone | |
0.0675 | - |
at pH 9.0 | Glycine max | 2'-hydroxy-3,4-dimethoxy-chalcone | |
0.07 | - |
at pH 9.0 | Glycine max | 4'-methoxy-aurone | |
0.082 | - |
at pH 9.0 | Glycine max | 2'-hydroxy-4-chloro-4', 6'-dimethoxy-chalcone | |
0.1 | - |
at pH 9.0 | Glycine max | 2'-hydroxy-2-methoxy-chalcone | |
0.1 | - |
at pH 9.0 | Glycine max | 2',4,6-trimethoxy-aurone | |
0.6 | - |
at pH 9.0 | Glycine max | caffeic acid |