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Literature summary for 1.13.11.11 extracted from

  • Basran, J.; Booth, E.S.; Campbell, L.P.; Thackray, S.J.; Jesani, M.H.; Clayden, J.; Moody, P.C.E.; Mowat, C.G.; Kwon, H.; Raven, E.L.
    Binding of L-kynurenine to X. campestris tryptophan 2,3-dioxygenase (2021), J. Inorg. Biochem., 225, 111604 .
    View publication on PubMed
Search for more literature for 1.13.11.11

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the enzyme in complex with L-kynurenine Xanthomonas campestris
crystal structure of the enzyme in complex with L-kynurenine Xanthomonas campestris pv. campestris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Xanthomonas campestris
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Xanthomonas campestris pv. campestris
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Xanthomonas campestris pv. campestris ATCC 33913
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Xanthomonas campestris
-
-
-
Xanthomonas campestris pv. campestris Q8PDA8
-
-
Xanthomonas campestris pv. campestris ATCC 33913 Q8PDA8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Xanthomonas campestris N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Xanthomonas campestris pv. campestris N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Xanthomonas campestris pv. campestris ATCC 33913 N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
TDO
-
 Xanthomonas campestris pv. campestris

Cofactor

Cofactor Comment Organism Structure
heme heme-dependent enzyme Xanthomonas campestris pv. campestris

General Information

General Information Comment Organism
physiological function the kynurenine pathway is the major route of tryptophan metabolism. The first step of this pathway is catalysed by one of two heme-dependent dioxygenase enzymes - tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) - leading initially to the formation of N-formylkynurenine Xanthomonas campestris