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Literature summary for 1.13.11.11 extracted from

  • Chang, Y.; Han, P.; Wang, Y.; Jia, C.; Zhang, B.; Zhao, Y.; Li, S.; Li, S.; Wang, X.; Yang, X.; Wei, W.
    Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis (2022), Br. J. Pharmacol., 179, 3024-3042 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Rattus norvegicus
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P48775
-
-
Rattus norvegicus P21643 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis Rattus norvegicus
-
leukocyte immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis Homo sapiens
-
synoviocyte
-
 Rattus norvegicus
-
synoviocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Rattus norvegicus N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
TDO2
-
 Rattus norvegicus
TDO2
-
 Homo sapiens
tryptophan 2,3-dioxygenase 2
-
 Rattus norvegicus
tryptophan 2,3-dioxygenase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Rattus norvegicus expression is strongly increased in synovial tissue and fibroblast-like synoviocytes of rheumatoid arthritis and adjuvant-induced arthritis. Immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis up
Homo sapiens expression is strongly increased in synovial tissue and fibroblast-like synoviocytes of rheumatoid arthritis and adjuvant-induced arthritis. Immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis up

General Information

General Information Comment Organism
malfunction pharmacological inhibition or knockdown of the enzyme (TDO2) in adjuvant-induced arthritis-fibroblast-like synoviocytes results in a reduced proliferation, secretion, migration and invasion Rattus norvegicus
malfunction pharmacological inhibition or knockdown of the enzyme (TDO2) in adjuvant-induced arthritis-fibroblast-like synoviocytes results in a reduced proliferation, secretion, migration and invasion Homo sapiens
physiological function the enzyme plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis Rattus norvegicus
physiological function the enzyme plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis Homo sapiens