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Literature summary for 1.12.99.6 extracted from

  • Yang, C.; Li, Z.; Zhao, D.; Chen, J.; Zhu, X.; Zhang, X.; Bi, C.
    Engineering an efficient H2 utilizing Escherichia coli platform by modulation of endogenous hydrogenases (2021), Biochem. Eng. J., 166, 107851 .
No PubMed abstract available

Application

Application Comment Organism
synthesis endogenous hydrogenases Hyd-1 and Hyd-2 can be utilized to engineer H2 in a microbial cell factory manner Escherichia coli
synthesis hydrogenases Hyd-1 and Hyd-2 are engineered to enable the cells to efficiently utilize hydrogen gas as a source of reducing equivalents, which increased the yield of reduced fermentation products, e.g. succinate or lactate. By upregulating the expression of the hydrogenase, the spectrum of fermentation products shifts toward the reductive end compared to that of the wild type Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Escherichia coli ATCC 8739
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Synonyms

Synonyms Comment Organism
hydrogenases Hyd-1
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Escherichia coli
hydrogenases Hyd-2
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Escherichia coli

General Information

General Information Comment Organism
physiological function endogenous hydrogenases Hyd-1 and Hyd-2 induce respective 26.5 % and 36.7 % increases of succinate yield, indicating that both Hyd-1 and Hyd-2 contribute to the increased pool of reductive equivalents Escherichia coli