Literature summary for 1.12.99.6 extracted from

Parkin, A.; Goldet, G.; Cavazza, C.; Fontecilla-Camps, J.C.; Armstrong, F.A.
The difference a Se makes? Oxygen-tolerant hydrogen production by the [NiFeSe]-hydrogenase from Desulfomicrobium baculatum (2008), J. Am. Chem. Soc., 130, 13410-13416.

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Inhibitors

Inhibitors	Comment	Organism	Structure
O2	reacts with the enzyme, reversibly, causing inactivation. Although traces of O2 (less than 1%) rapidly and completely remove H2 oxidation activity, the enzyme sustains partial activity for H2 production even in the presence of 1% O2 in the atmosphere. O2 tolerance of the [NiFeSe]-hydrogenase is greater at higher temperature	Desulfomicrobium baculatum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe	[NiFeSe]-hydrogenase, absence of a [3Fe-4S] cluster	Desulfomicrobium baculatum
Ni2+	[NiFeSe]-hydrogenase	Desulfomicrobium baculatum
selenium	[NiFeSe]-hydrogenase	Desulfomicrobium baculatum

Organism

Organism	UniProt	Comment	Textmining
Desulfomicrobium baculatum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2 + oxidized acceptor	[NiFeSe]-hydrogenase is a highly efficient H2 cycling catalyst	Desulfomicrobium baculatum	H+ + reduced acceptor	-	?

Synonyms

Synonyms	Comment	Organism
[NiFeSe]-hydrogenase	-	Desulfomicrobium baculatum

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Release 2023.1 (January 2023)