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Literature summary for 1.11.2.6 extracted from

  • Wang, Y.; Davis, I.; Shin, I.; Wherritt, D.J.; Griffith, W.P.; Dornevil, K.; Colabroy, K.L.; Liu, A.
    Biocatalytic carbon-hydrogen and carbon-fluorine bond cleavage through hydroxylation promoted by a histidyl-ligated heme enzyme (2019), ACS Catal., 9, 4764-4776 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.11.2.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Streptomyces lincolnensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + H2O2 Streptomyces lincolnensis
-
 L-dopa + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces lincolnensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-affinity column chromatography and Sephadex G-25 gel filtration Streptomyces lincolnensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-chloro-L-tyrosine + H2O2 the enzyme performs oxidative C-H bond cleavage at C5 to generate 3-chloro-5-hydroxyl-L-tyrosine and oxygenation at C3 concomitant with a carbon-fluorine bond cleavage to yield L-dopa and chloride Streptomyces lincolnensis 3-chloro-5-hydroxyl-L-tyrosine + L-dopa + Cl-
-
 ?
3-fluoro-L-tyrosine + H2O2 the enzyme performs oxidative C-H bond cleavage at C5 to generate 3-fluoro-5-hydroxyl-L-tyrosine and oxygenation at C3 concomitant with a carbon-fluorine bond cleavage to yield L-dopa and fluoride Streptomyces lincolnensis 3-fluoro-5-hydroxyl-L-tyrosine + L-dopa + F-
-
 ?
3-iodo-L-tyrosine + H2O2 the enzyme performs oxidative C-H bond cleavage at C5 to generate 3-iodo-5-hydroxyl-L-tyrosine and oxygenation at C3 concomitant with a carbon-fluorine bond cleavage to yield L-dopa and iodide Streptomyces lincolnensis 3-iodo-5-hydroxyl-L-tyrosine + L-dopa + I-
-
 ?
3-nitro-L-tyrosine + H2O2
-
 Streptomyces lincolnensis 3-nitro-5-hydroxyl-L-tyrosine + H2O
-
 ?
L-tyrosine + H2O2
-
 Streptomyces lincolnensis L-dopa + H2O
-
 ?
additional information no activity with L-phenylalanine and O-methyl-L-tyrosine Streptomyces lincolnensis ?
-
-

Synonyms

Synonyms Comment Organism
LmbB2
-
 Streptomyces lincolnensis
TyrH
-
 Streptomyces lincolnensis

Cofactor

Cofactor Comment Organism Structure
heme
-
 Streptomyces lincolnensis