Any feedback?
Literature summary for 1.11.2.2 extracted from
- Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs (2014), Arch. Biochem. Biophys., 548, 74-85 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-aminobenzoic acid hydrazide | - |
Homo sapiens |  |
| 3-(dimethylamino) benzoic acid hydrazide | - |
Homo sapiens | |
| 4-(trifluoromethyl) benzoic acid hydrazide | - |
Homo sapiens | |
| 4-amino benzoic acid hydrazide | - |
Homo sapiens | |
| 4-fluorobenzoic acid hydrazide | - |
Homo sapiens | |
| 4-nitrobenzoic acid hydrazide | - |
Homo sapiens | |
| benzoic acid hydrazide | - |
Homo sapiens | |
| isoniazid | - |
Homo sapiens | |
| NaN3 | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.031 | - |
10-acetyl-3,7-dihydroxyphenoxazine | at pH 5.6 and 25°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cl- + H2O2 + H+ | Homo sapiens | - |
HClO + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P05164 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-acetyl-3,7-dihydroxyphenoxazine + H2O2 + H+ | - |
Homo sapiens | resorufin + H2O | - |
? | |
| Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MPO | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 186 | - |
10-acetyl-3,7-dihydroxyphenoxazine | at pH 5.6 and 25°C | Homo sapiens | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00024 | - |
4-amino benzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.00026 | - |
2-aminobenzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.00056 | - |
3-(dimethylamino) benzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.00069 | - |
benzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.00083 | - |
4-fluorobenzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.00084 | - |
NaN3 | at pH 5.6 and 25°C | Homo sapiens | |
| 0.00308 | - |
4-(trifluoromethyl) benzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.0037 | - |
4-nitrobenzoic acid hydrazide | at pH 5.6 and 25°C | Homo sapiens | |
| 0.01 | - |
isoniazid | at pH 5.6 and 25°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
at pH 5.6 and 25°C | Homo sapiens | 2-aminobenzoic acid hydrazide | |
| 0.00071 | - |
at pH 5.6 and 25°C | Homo sapiens | 4-amino benzoic acid hydrazide | |
| 0.00127 | - |
at pH 5.6 and 25°C | Homo sapiens | 3-(dimethylamino) benzoic acid hydrazide | |
| 0.00657 | - |
at pH 5.6 and 25°C | Homo sapiens | NaN3 | |
| 0.02245 | - |
at pH 5.6 and 25°C | Homo sapiens | 4-fluorobenzoic acid hydrazide | |
| 0.04083 | - |
at pH 5.6 and 25°C | Homo sapiens | benzoic acid hydrazide | |
| 0.05462 | - |
at pH 5.6 and 25°C | Homo sapiens | 4-nitrobenzoic acid hydrazide | |
| 0.1427 | - |
at pH 5.6 and 25°C | Homo sapiens | 4-(trifluoromethyl) benzoic acid hydrazide | |
| 0.2771 | - |
at pH 5.6 and 25°C | Homo sapiens | isoniazid | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
