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Literature summary for 1.11.2.2 extracted from
- The chlorinating activity of human myeloperoxidase: high initial activity at neutral pH value and activation by electron donors (1990), Biochim. Biophys. Acta, 1037, 140-146.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-aminosalicylic acid | converts inactive myeloperoxidase compound II rapidly into active myeloperoxidase | Homo sapiens |  |
| ascorbic acid | converts inactive myeloperoxidase compound II into active myeloperoxidase | Homo sapiens | |
| ferrocyanide | converts inactive myeloperoxidase compound II into active myeloperoxidase | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
H2O2 | apparent value, measured after 100 ms, in 50 mM phosphate buffer, at pH 7.2 and 20°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cl- + H2O2 + H+ | Homo sapiens | - |
HClO + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? | |
| monochlorodimedone + H2O2 | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| donor:hydrogen-peroxide oxidoreductase | - |
Homo sapiens |
| MPO | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 13 | - |
H2O2 | apparent value, measured after 15 s, in 50 mM phosphate buffer, at pH 7.2 and 20°C | Homo sapiens | |
| 25 | - |
H2O2 | apparent value, measured after 1 s, in 50 mM phosphate buffer, at pH 7.2 and 20°C | Homo sapiens | |
| 320 | - |
H2O2 | apparent value, measured after 100 ms, in 50 mM phosphate buffer, at pH 7.2 and 20°C | Homo sapiens | |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
the enzymic activity at pH 7.2 rapidly declines in time (from 100 ms up to 15 s) | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
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