Activating Compound | Comment | Organism | Structure |
---|---|---|---|
chloride | in the presence of 100 mM NaCl the catalytic efficiency of MPO increases 3-4fold whatever the sulfide considered, the rate of 4-tolyl methyl sulphide oxidation enhancement is about 8fold at 120 mM NaCl | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H2O2 | at pH 5.0, H2O2 at high concentrations inhibits the enzyme. The rate of sulfoxide formation increases as the H2O2 concentration increases up to 0.2 mM, while a further increase in concentration results in a decrease in the rate of sulfoxide formation (40% inhibition at 1 mM H2O2) | Homo sapiens | |
Sulfide | at high sulfide concentrations, enzymic inhibition is observed above 0.25 mM (20% inhibition at 0.3 mM sulfide) | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
1-methoxy-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.016 | - |
1-acetyl-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.018 | - |
thioanisole | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.02 | - |
thioanisole | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.026 | - |
phenyl propan-2-yl sulfide | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.027 | - |
1-chloro-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.03 | - |
1-methoxy-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.032 | - |
1-methyl-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.039 | - |
1-acetyl-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.04 | - |
1-methyl-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.041 | - |
phenyl propan-2-yl sulfide | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.05 | - |
benzyl methyl sulfide | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.057 | - |
4-(methylsulfanyl)aniline | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.066 | - |
1-nitro-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.067 | - |
1-chloro-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.07 | - |
H2O2 | in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.072 | - |
benzothiophene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.076 | - |
1-nitro-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.081 | - |
benzothiophene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.083 | - |
benzyl methyl sulfide | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
0.104 | - |
4-(methylsulfanyl)aniline | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acetyl-4-(methylsulfanyl)benzene + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
1-chloro-4-(methylsulfanyl)benzene + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
1-methoxy-4-(methylsulfanyl)benzene + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
1-methyl-4-(methylsulfanyl)benzene + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
1-nitro-4-(methylsulfanyl)benzene + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
4-(methylsulfanyl)aniline + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
4-tolyl methyl sulfide + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
benzothiophene + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
benzyl methyl sulfide + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? | |
phenyl propan-2-yl sulfide + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
thioanisole + H2O2 + H+ | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.43 | - |
1-methoxy-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
1 | - |
benzyl methyl sulfide | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
1 | - |
benzothiophene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
1.6 | - |
benzothiophene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
1.8 | - |
1-nitro-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
3 | - |
1-methyl-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
4 | - |
thioanisole | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
4.2 | - |
1-acetyl-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
5 | - |
1-chloro-4-(methylsulfanyl)benzene | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
5.5 | - |
1-nitro-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
6 | - |
1-methoxy-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
7.3 | - |
phenyl propan-2-yl sulfide | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
8 | - |
benzyl methyl sulfide | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
10 | - |
4-(methylsulfanyl)aniline | in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
12 | - |
thioanisole | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
14 | - |
phenyl propan-2-yl sulfide | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
20 | - |
1-methyl-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
35 | - |
1-chloro-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
40 | - |
4-(methylsulfanyl)aniline | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens | |
56 | - |
1-acetyl-4-(methylsulfanyl)benzene | in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |