Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.11.1.9 extracted from

  • Hu, J.; An, B.; Pan, T.; Li, Z.; Huang, L.; Li, X.
    Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimers disease (2018), Bioorg. Med. Chem., 26, 5718-5729 .
    View publication on PubMed
Search for more literature for 1.11.1.9

Organism

Organism UniProt Comment Textmining
synthetic construct
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 glutathione + cumene hydroperoxide
-
 synthetic construct glutathione disulfide + 2-phenylpropan-2-ol + H2O
-
 ?
2 glutathione + H2O2
-
 synthetic construct glutathione disulfide + 2 H2O
-
 r
2 glutathione + tert-butyl hydroperoxide
-
 synthetic construct glutathione disulfide + tert-butyl alcohol + H2O
-
 ?
additional information compounds N-hydroxy-4-((3-oxobenzo[d][1,2]selenazol-2(3H)-yl)methyl)benzamide and N-hydroxy-4-(1-(3-oxobenzo[d][1,2]selenazol-2(3H)-yl)ethyl)benzamide demonstrate good catalytic peroxidase-like activity, with rate values that are similar to ebselen's value. Compound N-hydroxy-4-((3-oxobenzo[d][1,2]selenazol-2(3H)-yl)methyl)benzamide is a histone deacetylase inhibitor, possessing rapid hydrogen peroxide scavenging activity and good free oxygen radical absorbance capacity synthetic construct ?
-
-

General Information

General Information Comment Organism
physiological function compound shows glutathione peroxidase-like activity synthetic construct