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Literature summary for 1.11.1.9 extracted from

  • Kang, J.M.; Ju, H.L.; Sohn, W.M.; Na, B.K.
    Characterization of biochemical properties of a selenium-independent glutathione peroxidase of Cryptosporidium parvum (2014), Parasitology, 141, 570-578 .
    View publication on PubMed
Search for more literature for 1.11.1.9

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: potassium cyanide or sodium azide Cryptosporidium parvum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Cryptosporidium parvum 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 gel filtration Cryptosporidium parvum

Organism

Organism UniProt Comment Textmining
Cryptosporidium parvum Q5CV33
-
-
Cryptosporidium parvum Iowa II Q5CV33
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
84.3
-
 substrate cumene hydroperoxide, 37°C, pH 7.6 Cryptosporidium parvum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 glutathione + H2O2
-
 Cryptosporidium parvum glutathione disulfide + 2 H2O
-
 ?
2 glutathione + H2O2
-
 Cryptosporidium parvum Iowa II glutathione disulfide + 2 H2O
-
 ?
cumene hydroperoxide + 2 GSH
-
 Cryptosporidium parvum 2-phenylpropan-2-ol + GSSG + H2O
-
 ?
cumene hydroperoxide + 2 GSH
-
 Cryptosporidium parvum Iowa II 2-phenylpropan-2-ol + GSSG + H2O
-
 ?
additional information enzyme shows substrate preference against organic hydroperoxides, such as cumene-OOH and t-butyl-OOH, and low activity against H2O2 Cryptosporidium parvum ?
-
 ?
additional information enzyme shows substrate preference against organic hydroperoxides, such as cumene-OOH and t-butyl-OOH, and low activity against H2O2 Cryptosporidium parvum Iowa II ?
-
 ?
tert-butyl hydroperoxide + 2 GSH
-
 Cryptosporidium parvum tert-butyl alcohol + GSSG + H2O
-
 ?
tert-butyl hydroperoxide + 2 GSH
-
 Cryptosporidium parvum Iowa II tert-butyl alcohol + GSSG + H2O
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 24800, calculated, 1 * 25000, SDS-PAGE Cryptosporidium parvum

Synonyms

Synonyms Comment Organism
cgd3_460
-
 Cryptosporidium parvum

Expression

Organism Comment Expression
Cryptosporidium parvum the GPx gene contains a standard UGU codon for cysteine instead of a UGA opal codon for seleno-cysteine at the active site, and no selenoocysteine insertion sequence motif is identified within the 3'-untranslated region additional information

General Information

General Information Comment Organism
physiological function the enzyme effectively protects DNA and protein from oxidative damage induced by hydrogen peroxide Cryptosporidium parvum