Literature summary for 1.11.1.9 extracted from

Hidalgo, M.; Marchant, D.; Quidu, P.; Youcef-Ali, K.; Richalet, J.P.; Beaudry, M.; Besse, S.; Launay, T.
Oxygen modulates the glutathione peroxidase activity during the L6 myoblast early differentiation process (2014), Cell. Physiol. Biochem., 33, 67-77 .

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
myoblast	L6 myoblast	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
tert-butyl hydroperoxide + 2 GSH	-	Rattus norvegicus	tert-butyl alcohol + GSSG + H2O	-	?

General Information

General Information	Comment	Organism
metabolism	presence of 5% O2 improves the glutathione peroxidase activity, p110-PI3K/Thr308-Akt pathway and differentiation while 1% O2 decreases all these parameters compared to 21% O2. N-acetylcysteine (0.5 mM) can prevent the deleterious effects of hypoxia (1% O2) on the L6 myoblast proliferation and enhances the myoblast differentiation when exposed to 21% O2	Rattus norvegicus

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Release 2023.1 (January 2023)