Literature summary for 1.11.1.9 extracted from

Zhang, L.; Liu, X.; Chen, L.; You, L.; Pei, D.; Cong, M.; Zhao, J.; Li, C.; Liu, D.; Yu, J.; Wu, H.
Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge (2011), Fish Shellfish Immunol., 31, 831-837.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Ruditapes philippinarum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
selenium	dependent on	Ruditapes philippinarum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glutathione + H2O2	Ruditapes philippinarum	-	glutathione disulfide + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Ruditapes philippinarum	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adductor muscle	low expression	Ruditapes philippinarum	-
gill	low expression	Ruditapes philippinarum	-
hemocyte	low expression	Ruditapes philippinarum	-
hepatopancreas	most abundantly expressed in hepatopancreas	Ruditapes philippinarum	-
mantle	low expression	Ruditapes philippinarum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione + H2O2	-	Ruditapes philippinarum	glutathione disulfide + H2O	-	?

Synonyms

Synonyms	Comment	Organism
Se-GPx	-	Ruditapes philippinarum
selenium-dependent glutathione peroxidase	-	Ruditapes philippinarum

Expression

Organism	Comment	Expression
Ruditapes philippinarum	Vibrio challenge can significantly upregulate the mRNA expression of the enzyme, and the highest expression level (6.5fold) is detected at 24 h post infection with 6.5fold increase compared with that in the control group. Enzyme expression is significantly induced by 0.02 and 0.04 mg l-1 Cd (both 2.9fold after 24 h) and 0.01 and 0.02 mg l-1 Cu (2.7fold after 24 h and 1.6fold at 96 h, respectively). The mRNA expression is maximally induced (6.29fold) at 96 h post challenge with 0.05 mg l-1 benzo[a]pyrene	up

General Information

General Information	Comment	Organism
physiological function	the enzyme is potentially involved in mediating the immune response and antioxidant defense	Ruditapes philippinarum

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Release 2023.1 (January 2023)