Literature summary for 1.11.1.9 extracted from

  • Hiratsuka, A.; Yamane, H.; Yamazaki, S.; Ozawa, N.; Watabe, T.
    Subunit Ya-specific glutathione peroxidase activity toward cholesterol 7-hydroperoxides of glutathione S-transferases in cytosols from rat liver and skin (1997), J. Biol. Chem., 272, 4763-4769.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
cholesterol 7beta-hydroperoxide
-
Rattus norvegicus
0.004
-
cholesterol 5alpha-hydroperoxide
-
Rattus norvegicus
0.011
-
cholesterol 7alpha-hydroperoxide
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenocysteine Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + ROOH Rattus norvegicus
-
glutathione disulfide + ROH + H2O
-
?
linolenic acid hydroperoxide + GSH Rattus norvegicus
-
?
-
?
H2O2 + GSH Rattus norvegicus
-
H2O + GSSG
-
?
cumene hydroperoxide + GSH Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
skin
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1
-
cholesterol 7beta-hydroperoxide Rattus norvegicus
0.18
-
cholesterol 7alpha-hydroperoxide Rattus norvegicus
0.07
-
cholesterol 5alpha-hydroperoxide Rattus norvegicus
408
-
linoleic acid hydroperoxide Rattus norvegicus
511
-
arachidonic acid 15-hydroperoxide Rattus norvegicus
445
-
H2O2 Rattus norvegicus
472
-
cumene hydroperoxide Rattus norvegicus
402
-
linolenic acid hydroperoxide Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + ROOH
-
Rattus norvegicus glutathione disulfide + ROH + H2O
-
?
linolenic acid hydroperoxide + GSH
-
Rattus norvegicus ?
-
?
H2O2 + GSH
-
Rattus norvegicus H2O + GSSG
-
?
cumene hydroperoxide + GSH
-
Rattus norvegicus ?
-
?
cholesterol 7alpha-hydroperoxide + GSH
-
Rattus norvegicus 7alpha-hydroxycholesterol + GSSG
-
?
cholesterol 7beta-hydroperoxide + GSH
-
Rattus norvegicus 7beta-hydroxycholesterol + GSSG
-
?
cholesterol 5alpha-hydroperoxide + GSH
-
Rattus norvegicus 5alpha-hydroxycholesterol + GSSG
-
?
linoleic acid hydroperoxide + GSH
-
Rattus norvegicus ?
-
?
arachidonic acid 15-hydroperoxide + GSH
-
Rattus norvegicus 15-hydroxyarachidonic acid + GSSG
-
?