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Literature summary for 1.11.1.9 extracted from
- Transcriptional activation of the human glutathione peroxidase promoter by p53 (1999), J. Biol. Chem., 274, 12061-12066.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| etoposide | activates p53, wich induces the expression of glutathione peroxidase | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + ROOH | Homo sapiens | - |
glutathione disulfide + ROH + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
Saos-2 cell line | - |
| Homo sapiens | - |
U2-OS cell line | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5 | - |
Saos-2 | Homo sapiens |
| 5.5 | - |
Saos-2 treated with etoposide | Homo sapiens |
| 6.7 | - |
U2-OS | Homo sapiens |
| 11.9 | - |
U2-OS treated with etoposide | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + ROOH | - |
Homo sapiens | glutathione disulfide + ROH + H2O | - |
? | |
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