Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.11.1.9 extracted from

  • Flohe, L.
    The selenoprotein glutathione peroxidase (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, , 643-731.
No PubMed abstract available
Search for more literature for 1.11.1.9

Inhibitors

Inhibitors Comment Organism Structure
additional information not: ophthalmic acid aves
additional information not: ophthalmic acid Chondrichthyes
additional information not: ophthalmic acid Mammalia
additional information not: ophthalmic acid Testudines
O2-
-
 aves
O2-
-
 Chondrichthyes
O2-
-
 Mammalia
O2-
-
 Testudines
Polyvalent anions e.g. phosphate, sulfate, maleate aves
Polyvalent anions e.g. phosphate, sulfate, maleate Chondrichthyes
Polyvalent anions e.g. phosphate, sulfate, maleate Mammalia
Polyvalent anions e.g. phosphate, sulfate, maleate Testudines

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mammalia 5829
-
mitochondrial matrix 25% of activity Mammalia 5759
-
additional information not in peroxisomes Mammalia
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenocysteine Mammalia
selenium selenocysteine Chondrichthyes
selenium selenocysteine aves
selenium selenocysteine Testudines

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + ROOH Mammalia broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?
glutathione + ROOH Chondrichthyes broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?
glutathione + ROOH aves broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?
glutathione + ROOH Testudines broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
aves
-
-
-
Chondrichthyes
-
-
-
Mammalia
-
-
-
no activity in plants
-
-
-
Testudines
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 glutathione + H2O2 = glutathione disulfide + 2 H2O mechanism Mammalia
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + ROOH broad specificity for hydroperoxides Mammalia glutathione disulfide + ROH + H2O
-
 ?
glutathione + ROOH broad specificity for hydroperoxides Chondrichthyes glutathione disulfide + ROH + H2O
-
 ?
glutathione + ROOH broad specificity for hydroperoxides aves glutathione disulfide + ROH + H2O
-
 ?
glutathione + ROOH broad specificity for hydroperoxides Testudines glutathione disulfide + ROH + H2O
-
 ?

Subunits

Subunits Comment Organism
homotetramer
-
 Mammalia