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Literature summary for 1.11.1.8 extracted from

  • Dong, H.; Godlewska, M.; Wade, M.G.
    A rapid assay of human thyroid peroxidase activity (2020), Toxicol. In Vitro, 62, 104662 .
    View publication on PubMed

Application

Application Comment Organism
analysis evaluation of a rapid assay for TPO inhibition, using a stable fluorescent product (Amplex UltraRed). The assay consistently identifies the relative potency of strong to moderate inhibitors and chemicals known to be inactive. Results are less consistent for chemicals reported to be weak inhibitors of rodent TPO Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO and LentiX-293 cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2',4,4'-tetrahydroxybenzophenone
-
Homo sapiens
2-mercaptobenzothiazole
-
Homo sapiens
6-Propyl-2-thiouracil
-
Homo sapiens
amino-1,2,4-triazole
-
Homo sapiens
genistein
-
Homo sapiens
Methimazole
-
Homo sapiens
resorcinol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07202
-
-

Source Tissue

Source Tissue Comment Organism Textmining